A monster machine and overkill:
Take a top of the line i7 or similar Phenom...
Get 3 way sli ability on your motherboard...
Sli 3 295 Geforces,
get 16 gb of RAM,
Liquid nitrogen Cooling.
Overclock to 6 GHZ on the AMD or equivlent on the intel,
boast.
I have a GTX 260, Phenon II 940 overclocked to 3.51Ghz (the North Bridge is also overclocked), 4 gbs or DDR2800 RAM (Slightly underclocked for stability), and a 750 GB hard drive.
Its awesome, and an oven for my computer.